Progesto­gens

What are progesto­gens?

The natural progestogen is progesterone. It is produced in the ovaries after ovulation. After the follicle ruptures and releases the egg, the follicle turns into the corpus luteum, which then starts producing progesterone.

Where does prog­es­terone act?

Progesterone prepares the body for the embryo to implant and for pregnancy.

Effects on the uterus

• Progesterone stops the growth of the lining of the uterus that was caused by oestrogens.
• It turns the lining of the uterus into a tissue rich in glands.
• It causes glycogen to be stored.
• It reduces contractions of the uterus.
• It closes the cervix.
• It reduces the amount of cervical mucus.

Effects on the rest of the body

• It suppresses the release of LH from the pituitary gland and so prevents ovulation.
• It promotes the development of the mammary glands.
• It raises body temperature.
• At high doses, it acts as an anabolic agent (increasing muscle mass).